Oxalic Acid → HCID 54000621, compound

Participants

Reaction Steps

A mixture of 2.66 g (7 mmol) of a compound II (R1, R2, R3, R5, R6 =H; R4 =CH3), 0.72 g (8 mmol) of anhydrous oxalic acid and 4.5 ml of glacial acetic acid was stirred at 85° for 1 hour and subsequently worked up as in Example 5. 1.58 g (=59.4% yield) of TLC-pure 4-amino-2-(2-oxo-1-imidazolidinyl)pyrimidine-5-carboxylic acid N-methyl-N-(3-trifluoromethylphenyl)amide were obtained, melting point 249°-250°.

Provenance & Evidence