Cyanoacetic acid → HCID 54488963, compound

Participants

Reaction Steps

A mixture of 2.84 g (7 mmol) of a compound II (R1 =CH=CH2 ; R2, R3, R5, R6 =H; R4 =CH3), 486 mg (5.5 mmol) of cyanoacetic acid and 5 ml of glacial acetic acid was stirred at 75° for 1.5 hours and subsequently worked up as in Example 5. Crystallization from ether resulted in 1.75 g (=61.6% yield) of 4-amino-2-(4-vinyl-2-oxo-1-imidazolidinyl)pyrimidine-5-carboxylic acid N-methyl-N-(3-trifluoromethylphenyl)amide, melting point 203°-204°.

Provenance & Evidence