Acetic Acid → HCID 67768983, compound

Participants

Reaction Steps

A mixture of 3.14 g (7 mmol) of a compound II (R1 =CH=CH2 ; R2, R3, R5, R6 =H; R4 =CH2CH(CH3)2), 5 ml of glacial acetic acid and 1.05 g (5.5 mmol) of p-toluenesulfonic acid monohydrate was stirred at 67°-69° for 2.5 hours and then worked up as in Example 5. 1.67 g (53.2% yield) of TLC-pure 4-amino-2-(4-vinyl-2-oxo-1-imidazolidinyl)pyrimidine-5-carboxylic acid N-isobutyl-N-(3-trifluoromethylphenyl)amide were obtained, melting point 85°-186°.

Provenance & Evidence