HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(1-Benzyl-1H-imidazo[4,5-c]pyridin-4-yloxy)-1-aza-bicyclo[2,2,2]octane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (+-)-3-Quinuclidinol | HCID 15381 | — |
| Reactant | 1-Benzyl-4-chloro-1H-imidazo[4,5-c]pyridine | HCID 14199152 | — |
| Product | 3-(1-Benzyl-1H-imidazo[4,5-c]pyridin-4-yloxy)-1-aza-bicyclo[2,2,2]octane | HCID 19694166 | 48.6% |
Reaction Steps
Following the procedure of Example 1, 1-benzyl-4-chloro-1H-imidazo[4,5-c]pyridine (0.78 g, 3.2 mmol) was treated with 3-quinuclidinol (0.44 g, 3.5 mmol) to give 0.52 g (39%) of the title compound as the hydrochloride, 2.5 hydrate: mp 162°-183° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05571819 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-9d71877efd564537848eb9e43ec36f90 |
| Source note | uspto-grants-1996_11 |