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Sodium Hydroxide → 1-Isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Ethyl 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylate | HCID 15468682 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1-Isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylic acid | HCID 10944290 | 88.3% |
反応手順
A solution of 1.55 g of ethyl 1-isopropyl-2(1H)-quinolone-3-carboxylate and 0.28 g of sodium hydroxide in a mixture of 10 ml of ethanol and 2 ml of water was stirred overnight at room temperature. After the solvent was distilled off, dil. hydrochloric acid was added to the residue. The precipitated solid was taken by filtration, washed with water and dried to give 1.22 g of 1-isopropyl-2(1H)-quinolone-3-carboxylic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05571820 |
| 出典データセット | uspto-grants-1996_11 |
| ORD ID | ord-517c823989d348d195c3c138d15bd565 |
| 出典メモ | uspto-grants-1996_11 |