Methyl Thioglycolate → HCID 54266254, compound

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Reaction Steps

Following the procedure of Example 4, 2,2'-dimethoxybenzhydrol, synthesized in accordance with M. L. Hoefle, et. al. in J. Med. Chem. 34, 7 (1971)] is reacted with methyl thioglycolate for 3 hours at 50°-60° C. followed by 18 hours at room temperature. Chromatography on silica gel, eluting with a gradient of 10% ethyl acetate in hexane to 20% ethyl acetate in hexane, followed by additional chromatography, eluting with a gradient of 5% ethyl acetate in hexane to 10% ethyl acetate in hexane, gives methyl [[bis-(2-methoxyphenyl)methyl]thio]acetate as a white solid in 72% yield: melting point 65°-67° C.

Provenance & Evidence