Methyl Thioglycolate → HCID 54383689, compound

Participants

Reaction Steps

A solution of 9-bromo-9-phenylfluorene (Aldrich) (1.9 g, 5.9 mmol) and methyl thioglycolate (0.70 mL, 7.8 mmol) in 50 mL of toluene is heated at reflux for 4 hours. The reaction is cooled and concentrated in vacuo. The resulting oil is chromatographed on silica gel eluting with a gradient of ethyl acetate/toluene/hexane (3:20:77 to 5:40:55). The purified product is co-evaporated with hexane 2 times and dried under vacuum for 3 days to give 1.6 g (77%) of methyl (9-phenylfluoren-9-yl-thio)acetate as an oil.

Provenance & Evidence