Dicyclohexylcarbodiimide → HCID 70182183, compound

Participants

Reaction Steps

To a solution of BOC-glycine (0.47 g, 2.69 mmol) in EtOAc (10 mL) was added HOBT hydrate (0.49 g, 3.22 mmol) followed by DCC (0.66 g, 3.22 mmol). After 30 minutes, a solution of benzyloxyethylamine (0.41 g, 2.69 mmol) in EtOAc (5 mL) was added and the mixture was stirred overnight at room temperature. The mixture was filtered, and the filtrate was diluted with EtOAc, washed with saturated aqueous NaHCO3, brine, dried over MgSO4, and concentrated. Flash chromatography (EtOAc) gave 0.72 g (87%) of the title compound as a light yellow oil which slowly solidified; CI-MS 309 (m+1).

Provenance & Evidence