N-[2-(Phenylmethoxy)ethyl]-N2-[[4-(phenylmethoxy)phenyl]methyl]glycinamide → HCID 178521300, compound

HRID 1898980Notes

Reaction equation

HRID 1898980 reaction equation
C1(CO[CH2:9][CH2:10][NH:11][C:12](=[O:30])[CH2:13][NH:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19](OCC3C=CC=CC=3)=[CH:18][CH:17]=2)C=CC=CC=1.[C:31]([NH:41][C@H:42]([C:49]([OH:51])=O)[CH2:43][C:44]1[N:48]=[CH:47][NH:46][CH:45]=1)([O:33][CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)=[O:32].C(N[C@@H](C(O)=O)CC1N=CNC=1)(O[CH2:55][C:56]1[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=1)=O>>[C:35]1([CH2:34][O:33][C:31]([NH:41][C@H:42]([C:49]([N:14]([CH2:15][C:16]2[CH:17]=[CH:18][C:19]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:20][CH:21]=2)[CH2:13][C:12]([NH:11][CH2:10][CH2:9][CH2:55][C:56]2[CH:57]=[CH:58][CH:59]=[CH:60][CH:61]=2)=[O:30])=[O:51])[CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)=[O:32])[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=1

Participants

4

Reactant 3

HCID 70182186N-[2-(Phenylmethoxy)ethyl]-N2-[[4-(phenylmethoxy)phenyl]methyl]glycinamideHCID 178523877HCID 178523877, compoundHCID 178523878Z-D-His-OH

Product 1

HCID 178521300HCID 178521300, compound

Procedure

According to Example 10, Step 4, by substituting the compound from Step 1 above for N-[2-(phenylmethoxy)ethyl]-N2 -[[4-(phenylmethoxy)phenyl]methyl]glycinamide and CBZ-histidine for CBZ-D-histidine, the title compound was obtained as a white foam; ES-MS 646 (m+1).

Sources & evidence

ORD record
ord-7e0d489899f342279356485a83e1f4ac
Source dataset
uspto-grants-1996_11
Patent number
US05571792

Reaction notes

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