HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 2-(4-Chloro-5-methoxy-1H-indol-3-yl)acetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | 3-Dimethylaminomethyl-4-chloro-5-methoxy-indole | HCID 23373056 | — |
| Product | 2-(4-Chloro-5-methoxy-1H-indol-3-yl)acetonitrile | HCID 23373047 | 91.2% |
Reaction Steps
Reaction of 3-dimethylaminomethyl-4-chloro-5-methoxy-indole (2.00 g, 8.40 mmol) with potassium cyanide (2.08 g, 32.0 mmol) and methyl iodide (4.72 g, 33.0 mmol) and subsequent workup as described in 1 (d) gave 3-cyanomethyl-4-chloro-5-methoxyindole (1.69 g), m.p. 138°-9° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05571833 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-3c69a911ba344ad0b0fe9b2eb2dc98f5 |
| Source note | uspto-grants-1996_11 |