Acetic Anhydride → HCID 23373045, compound

Participants

Reaction Steps

To a mixture of formic acid (90%, 1.25 ml) and acetic anhydride (2.75 ml) was added 3-(2-aminoethyl)-4-chloro-5-methoxyindole (220 mg, 0.98 mmol), and the solution was stirred for 10 minutes. Removal of volatile components in vacuo at 30° C. left a residue which was partitioned between aqueous sodium bicarbonate and chloroform. The organic phase was separated, dried (Na2SO4) and evaporated to dryness. Purification by chromatography (SiO2 ; C6H14 /CHCl3) gave 3-(2-formylaminoethyl)-4-chloro-5-methoxyindole (176 mg) m.p. 120-121° C.

Provenance & Evidence