Trifluoroacetic acid → (S)-2-amino-3-cyclohexyl-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-propionamide trifluoroacetate

Participants

Reaction Steps

A solution of {(S)-2-cyclohexyl-1-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-ylcarbamoyl]-ethyl}-carbamic acid t-butyl ester (0.61 g 1.5 mmol) in dichloromethane (10 mL) was treated with trifluoroacetic acid (5 mL). The mixture was stirred at room temperature for 0.5 h, and concentrated to afford (S)-2-amino-3-cyclohexyl-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-propionamide trifluoroacetate (630 mg, 100%) as a white solid.

Provenance & Evidence