Dimethylformamide → HCID 54157120, compound

Participants

Reaction Steps

A mixture of phosphorus oxychloride (1.6 ml) and N,N-dimethylformamide (1.8 ml) in dichloroethane (6 ml) was stirred at ambient temperature for 1 hour. Dichloroethane (11 ml) and 4'-fluoro-2-(4-nitrophenyl)acetophenone (3 g) was added, and the mixture was refluxed overnight, washed with water twice, dried and evaporated. The oily residue (4 g) was purified by column chromatography on silica gel (80 g) eluting with toluene to give yellow crystals of 3-chloro-3-(4-fluorophenyl)-2-(4-nitrophenyl)propenal (2.9 g).

Provenance & Evidence