反应详情

A mixture of 3,4-difluorophenylacetic acid (10 g), 4-(methylthio)benzaldehyde (8.84 g) and sodium methoxide (3.14 g) in acetic anhydride (30 ml) was refluxed for 20 hours. The solvent was evaporated, and the residue was dissolved in ethyl acetate, washed with dilute hydrochloric acid and water, dried and concentrated to dryness. The obtained solid material was washed with ethanol and dried to give crystals of 2-(3,4-difluorophenyl)-3-[4-(methylthio)phenyl]acrylic acid (12.1 g).

1. temperaturewas refluxed for 20 hours
2. customThe solvent was evaporated
3. dissolutionthe residue was dissolved in ethyl acetate
4. washwashed with dilute hydrochloric acid and water
5. customdried
6. concentrationconcentrated to dryness
7. washThe obtained solid material was washed with ethanol
8. customdried