Bromine → HCID 23372681, compound

HRID 1899069Notes

Reaction equation

HRID 1899069 reaction equation
[Br:1]Br.[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[S:11][CH:12]=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=2)=[CH:6][CH:5]=1>C(O)(=O)C.ClCCl>[Br:1][C:12]1[S:11][C:10]([C:7]2[CH:6]=[CH:5][C:4]([F:3])=[CH:9][CH:8]=2)=[C:14]([C:15]2[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=2)[CH:13]=1

Participants

5

Reactant 2

HCID 24408BromineHCID 23372782HCID 23372782, compound

Product 1

HCID 23372681HCID 23372681, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 6344DichloromethaneSolvent

Conditions

Temperature
2 °C

Procedure

Bromine (1 ml) was added dropwise to a solution of 2-(4-fluorophenyl)-3-(4-nitrophenyl)thiophene (5.3 g) in acetic acid (53 ml) and dichloromethane (53 ml) at 2° C. The mixture was stirred at 2° C. for 45 minutes and concentrated to dryness. The residue was collected and washed with water and ethanol to give dark green crystals of 5-bromo-2-(4-fluorophenyl)-3-(4-nitrophenyl)thiophene (6.5 g).

Workup

  1. concentrationconcentrated to dryness
  2. customThe residue was collected
  3. washwashed with water and ethanol

Sources & evidence

ORD record
ord-4d1ca919040d4b158e6ea83043b61521
Source dataset
uspto-grants-1996_11
Patent number
US05571810

Reaction notes

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