Methanesulfonyl chloride → HCID 10642083, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]thiophene-2-carboxamide (4.8 g) and methanesulfonyl chloride (8.8 g) in pyridine (25 ml) was stirred at 50° C. for 4 hours. The mixture was concentrated and the residue was triturated in dilute hydrochloric acid. The precipitates were collected and recrystallized from ethanol to give crystals of 5-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]thiophene-2-carbonitrile (3.6 g).

Provenance & Evidence