Potassium Hydroxide → HCID 23372825, compound

Participants

Reaction Steps

A mixture of ethyl 5-(4-fluorophenyl)-4-(4-methoxyphenyl)thiophene-2-carboxylate (2.3 g) and potassium hydroxide (640 mg) in methanol (20 ml) was refluxed overnight. The solvent was evaporated, and the residue was dissolved in water, acidified and extracted with chloroform. The extract was washed with water, dried over magnesium sulfate and concentrated to dryness. The residue was washed with ethanol to give crystals of 5-(4-fluorophenyl)-4-(4-methoxyphenyl)thiophene-2-carboxylic acid (1.7 g).

Provenance & Evidence