反应详情

A mixture of 5-acetyl-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]thiophene (1 g) and sodium borohydride (0.12 g) in methanol (19 ml) was stirred at ambient temperature for 2 hours. Acetic acid (1 ml) was added and the mixture was concentrated. The residue was dissolved in ethyl acetate, washed with water and an aqueous solution of sodium bicarbonate, dried and concentrated. The residue was recrystallized from a mixture of hexane and ethyl acetate to give crystals of 2-(4-fluorophenyl)-5-(1-hydroxyethyl)-3-[4-(methylsulfonyl)phenyl]thiophene (0.74 g).

1. concentrationthe mixture was concentrated
2. dissolutionThe residue was dissolved in ethyl acetate
3. washwashed with water
4. dry with materialan aqueous solution of sodium bicarbonate, dried
5. concentrationconcentrated
6. customThe residue was recrystallized from a mixture of hexane and ethyl acetate