Thiourea → HCID 23372674, compound

Participants

Reaction Steps

A mixture of 5-(bromoacetyl)-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]thiophene (2 g) and thiourea (0.61 g) in ethanol (80 ml) was refluxed for 30 minutes. The mixture was dissolved in chloroform, washed with an aqueous solution of sodium bicarbonate and water, dried, and concentrated. The residue was purified by column chromatography on silica gel eluting with a mixture of chloroform and acetone (10:1) to give pale yellow crystals to 5-(2-amino-4-thiazolyl)-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]thiophene (0.62 g).

Provenance & Evidence