HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → 5-(4-Fluorophenyl)-4-[4-(methylsulfonyl)phenyl]thiophene-2-sulfonic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 2-(4-Fluorophenyl)-3-(4-methylsulfonylphenyl)thiophene | HCID 10336873 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-(4-Fluorophenyl)-4-[4-(methylsulfonyl)phenyl]thiophene-2-sulfonic acid | HCID 23372794 | — |
Reaction Steps
A mixture of 2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]thiophene (5 g), acetic anhydride (4.3 ml) and sulfuric acid (0.97 ml) in dichloromethane (47 ml) was stirred at ambient temperature overnight. The mixture was concentrated to give a crude blue oil of 5-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]thiophene-2-sulfonic acid (10.5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05571810 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-bb2e37dc350e4c0ea6b112174375cba2 |
| Source note | uspto-grants-1996_11 |