Hydrochloric Acid → HCID 66894995, compound

Participants

Reaction Conditions

Reaction Steps

To a solution containing 2-[4-(2,6-difluoro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-3-(2,6-difluoro-phenyl)-propionic acid ethyl ester (96 mg, 0.23 mmol) in tetrahydrofuran (1 mL) was treated with an aqueous solution of lithium hydroxide monohydrate (12 mg, 0.27 mmol) in water (2 mL). The mixture was stirred at 25° C. for 3 h, then acidified with 2N aqueous hydrochloric acid. The mixture was extracted with dichloromethane (2×30 mL). The combined organic layers were dried over magnesium sulfate and concentrated to afford 2-[4-(2,6-difluoro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-3-(2,6-difluoro-phenyl)-propionic acid (90 mg, 100%) as an off-white solid. LR-ES-MS m/z calculated for C19H13F4NO4 [M]+ 395, observed [M+H]+ 396.

Provenance & Evidence