Ammonium Chloride → HCID 178504665, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]thiophene-2-carbonitrile (3.1 g), sodium azide (1.3 g) and ammonium chloride (1.5 g) in N,N-dimethylformamide (30 ml) was stirred at 120° C. for 24 hours. The mixture was poured into ice-water, and the resulting mixture was acidified. The precipitates were collected and recrystallized from ethanol to give crystals of 2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-5-(5-tetrazolyl)thiophene (0.9 g).

Provenance & Evidence