1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(3-isopropylisoxazol-5-yl)urea → 1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1-hydroxy-2-methylpropan-2-yl)isoxazol-3-yl)urea
Reaction equation
[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6]([O:15][c:16]3[cH:17][c:18]([NH2:19])[cH:20][cH:21][cH:22]3)[n:7][cH:8][n:9][c:10]2[cH:11][c:12]1[O:13][CH3:14].[CH3:43][O:44][c:45]1[cH:46][c:47]2[c:48]([cH:49][c:50]1[O:51][CH3:52])[n:53][cH:54][n:55][c:56]2[O:57][c:58]1[cH:59][c:60]([NH:61][C:62]([NH:63][c:64]2[o:65][n:66][c:67]([CH:68]([CH3:69])[CH3:70])[cH:71]2)=[O:72])[cH:73][cH:74][cH:75]1.[OH:23][CH2:24][C:25]([CH3:26])([CH3:27])[c:28]1[cH:29][c:30]([NH:33][C:34]([O:35][c:37]2[cH:38][cH:39][cH:40][cH:41][cH:42]2)=[O:36])[n:31][o:32]1>>[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6]([O:15][c:16]3[cH:17][c:18]([NH:19][C:34]([NH:33][c:30]4[cH:29][c:28]([C:25]([CH2:24][OH:23])([CH3:26])[CH3:27])[o:32][n:31]4)=[O:35])[cH:20][cH:21][cH:22]3)[n:7][cH:8][n:9][c:10]2[cH:11][c:12]1[O:13][CH3:14]Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-2a14bb60d12842fba18720e936332655
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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