Acetonitrile → [4-(6-Fluoro1H-indazol-3-yl)-1-piperazinyl]acetonitrile

Participants

Reaction Steps

A mixture of 6-fluoro-3-(4-piperazinyl)-1H-indazole (6.0 g, 2.7 mmol), NaHCO3 (2.5 g, 3.0 mmol) chloroacetonitrile (2.5 g, 3.3 mmol) and CH3CN (150 mmol) was stirred at reflux under N2 for 18 hours. The cooled reaction was poured into H2O and the H2O, washed with brine, dried with MgSO4 and concentrated to yield 7.0 g of a tan solid. A 1.3 g sample was recrystallized from EtOAc to yield 0.65 g of a beige solid, m.p. 154°-156° C.

Provenance & Evidence