DIPCDI HOBt → HCID 178418600, Verbindung

HRID 1899384Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1899384
N1CCCCC1.CN(C=O)C.[NH:12](C(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O)[C@H:13]([C:35]([OH:37])=[O:36])[CH2:14][CH2:15][CH2:16][NH:17][C:18](=[NH:34])[NH:19]S(C1C(C)=C(C)C(OC)=CC=1C)(=O)=O.CC(N=C=NC(C)C)C.C1C=CC2N(O)N=NC=2C=1>CN(C=O)C>[NH2:12][C@H:13]([C:35]([OH:37])=[O:36])[CH2:14][CH2:15][CH2:16][NH:17][C:18](=[NH:19])[NH2:34]

Komponenten

5

Edukt 3

HCID 22603587DIPCDI HOBtHCID 23501187piperidine N,N-dimethylformamideHCID 178491779HCID 178491779, Verbindung

Produkt 1

HCID 178418600HCID 178418600, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

After removing the Fmoc groups of the DMBHA resin prepared in (1) with 20% piperidine/DMF, 2.5 eq of Fmoc-Arg(Mtr)-OH based on the DMBHA resin was added, and condensation reaction was carried out in DMF according to the DIPCDI-HOBt method.

Aufarbeitung

  1. customAfter removing the Fmoc groups of the DMBHA resin
  2. additionwas added
  3. customcondensation reaction

Quellen und Nachweise

ORD-Eintrag
ord-995f7c42718042ab8eaffe82699b33fe
Quelldatensatz
uspto-grants-1996_11
Patentnummer
US05571892

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