HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Difluoroaniline → 2-bromo-N-(2,4-difluorophenyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Difluoroaniline | HCID 9709 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Bromoacetyl chloride | HCID 89602 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-bromo-N-(2,4-difluorophenyl)acetamide | HCID 3416401 | — |
Reaction Steps
5.16 g (40 mmol) of 2,4-difluoroaniline and 6.3 g (40 mmol) of bromoacetyl chloride are treated in 200 ml of dichloromethane with 5.17 g (40 mmol) of Hunig base. After 4 h, the mixture is washed twice with 1N hydrochloric acid and once with water, dried (MgSO4) and concentrated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05571921 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-d4b3cbeaf5614edda9a0e9989ab48ab0 |
| Source note | uspto-grants-1996_11 |