HCID 23373391, compound → HCID 22448026, compound

Participants

Reaction Steps

4 g (10.12 mmol) of 1-[2-(2-nitrophenyl)amino-2-oxoethyl]-4-(2-oxo-1-benzimidazolinyl)piperidine are dissolved in 40 ml of DMF. After addition of 400 mg of 10% Pd/C (Aldrich), the mixture is hydrogenated at 3 bar until reaction is complete (TLC). The catalyst is filtered off and all solvent is stripped off in a high vacuum. The crude product is coevaporated several times with methanol. The crystals obtained are stirred in methanol, filtered off with suction and dried at 30° C. in a high vacuum.

Provenance & Evidence