HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine → HCID 178457149, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | 2-Di-n-propylamino-8-t-butoxycarbonylacetyl-1,2,3,4-tetrahydronaphthalene | HCID 23373520 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178457149 | HCID 178457149 | — |
Reaction Steps
Hydrazine (1 ml, 32 mmole) was added to a solution of 500 mg (1.34 mmole) of 2-di-n-propylamino-8-t-butoxycarbonylacetyl-1,2,3,4-tetrahydronaphthalene in 25 ml methanol and stirred at room temperature for for 24 hours. The product was isolated by concentrating the reaction mixture followed by flash chromatography, eluting with 1:1 CH2Cl2 :MeOH, and finally crystallizing from MeOH/EtOAc, m.p. 214°-216° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05571942 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-1058a3b1da8745469be2171a3c19ff3e |
| Source note | uspto-grants-1996_11 |