HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloro-3-methylbenzo(b)thiophene-2-sulfonyl chloride → N-(4-bromo-3-methyl-5-isoxazolyl)-5-chloro-3-methylbenzo[b]thiophene-2-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloro-3-methylbenzo(b)thiophene-2-sulfonyl chloride | HCID 2735756 | — |
| Reactant | 4-Bromo-3-methylisoxazol-5-amine | HCID 10487519 | — |
| Product | N-(4-bromo-3-methyl-5-isoxazolyl)-5-chloro-3-methylbenzo[b]thiophene-2-sulfonamide | HCID 15342060 | 18% |
Reaction Steps
N-(4-Bromo-3-methyl-5-isoxazolyl)-5-chloro-3-methylbenzo[b]thiophene-2-sulfonamide was prepared in the same manner as described in Example 2 from 5-amino-4-bromo-3-methylisoxazole and 5-chloro-3-methylbenzo[b]thiophene-2-sulphonyl chloride in 18% yield. Purification was achieved by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 153°-155° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05571821 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-37c9a177696f4d2ca13d7636b44af5df |
| Source note | uspto-grants-1996_11 |