4-(Propan-2-yl)benzene-1-sulfonyl chloride → HCID 15453205, compound

HRID 1899640Notes

Reaction equation

HRID 1899640 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[CH:9]([C:12]1[CH:17]=[CH:16][C:15]([S:18](Cl)(=[O:20])=[O:19])=[CH:14][CH:13]=1)([CH3:11])[CH3:10]>>[CH:9]([C:12]1[CH:17]=[CH:16][C:15]([S:18]([NH:1][C:2]2[O:6][N:5]=[C:4]([CH3:7])[C:3]=2[Br:8])(=[O:20])=[O:19])=[CH:14][CH:13]=1)([CH3:11])[CH3:10]

Participants

3

Reactant 2

HCID 27348824-(Propan-2-yl)benzene-1-sulfonyl chlorideHCID 104875194-Bromo-3-methylisoxazol-5-amine

Product 1

HCID 15453205HCID 15453205, compoundYield 77%

Procedure

4-iso-Propyl-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide was prepared in the same manner as described in Example 45 from 5-amino-4-bromo-3-methylisoxazole and 4-iso-propylbenzenesulfonyl chloride in 77% yield. Purification was achieved by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 130°-133° C.

Workup

  1. customPurification
  2. customwas achieved by recrystallization from ethyl acetate/hexanes
  3. customto give a crystalline solid, m.p. 130°-133° C.

Sources & evidence

ORD record
ord-bf28a7dd63434661b26a0ed00636971a
Source dataset
uspto-grants-1996_11
Patent number
US05571821

Reaction notes

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