3,4-Dimethoxybenzenesulfonyl chloride → HCID 15453210, compound

HRID 1899668Notes

Reaction equation

HRID 1899668 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[CH3:9][O:10][C:11]1[CH:12]=[C:13]([S:19](Cl)(=[O:21])=[O:20])[CH:14]=[CH:15][C:16]=1[O:17][CH3:18]>>[CH3:9][O:10][C:11]1[CH:12]=[C:13]([S:19]([NH:1][C:2]2[O:6][N:5]=[C:4]([CH3:7])[C:3]=2[Br:8])(=[O:20])=[O:21])[CH:14]=[CH:15][C:16]=1[O:17][CH3:18]

Participants

3

Reactant 2

HCID 27341833,4-Dimethoxybenzenesulfonyl chlorideHCID 104875194-Bromo-3-methylisoxazol-5-amine

Product 1

HCID 15453210HCID 15453210, compoundYield 64%

Procedure

3,4-Dimethoxy-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide was prepared from 5-amino-4-bromo-3-methylisoxazole and 3,4-dimethoxybenzenesulfonyl chloride according to the procedures described in Example 45. The crude product was purified by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 136°-138° C., yield 64%.

Workup

  1. customThe crude product was purified by recrystallization from ethyl acetate/hexanes
  2. customto give a crystalline solid, m.p. 136°-138° C., yield 64%

Sources & evidence

ORD record
ord-0ba874f0d9b148ffb94b1c19293a71c9
Source dataset
uspto-grants-1996_11
Patent number
US05571821

Reaction notes

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