Benzenesulfonyl chloride, 2,4-dichloro- → HCID 18617363, compound

HRID 1899669Notes

Reaction equation

HRID 1899669 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[Cl:9][C:10]1[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:11]=1[S:17](Cl)(=[O:19])=[O:18]>>[Cl:9][C:10]1[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:11]=1[S:17]([NH:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8])(=[O:19])=[O:18]

Participants

3

Reactant 2

HCID 204419Benzenesulfonyl chloride, 2,4-dichloro-HCID 104875194-Bromo-3-methylisoxazol-5-amine

Product 1

HCID 18617363HCID 18617363, compoundYield 46%

Procedure

2,4-Dichloro-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide was prepared from 5-amino-4-bromo-3-methylisoxazole and 2,4-dichlorobenzenesulfonyl chloride according to the procedures described in Example 45. The crude product was purified by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 138°-141° C., yield 46%.

Workup

  1. customThe crude product was purified by recrystallization from ethyl acetate/hexanes
  2. customto give a crystalline solid, m.p. 138°-141° C., yield 46%

Sources & evidence

ORD record
ord-dad0f598d64049679330e691d617a7b1
Source dataset
uspto-grants-1996_11
Patent number
US05571821

Reaction notes

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