Benzenesulfonyl chloride → HCID 18617378, compound

HRID 1899693Notes

Reaction equation

HRID 1899693 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([C:7]([F:10])([F:9])[F:8])[C:3]=1[CH2:11][CH3:12].[C:13]1([S:19](Cl)(=[O:21])=[O:20])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH2:11]([C:3]1[C:4]([C:7]([F:10])([F:9])[F:8])=[N:5][O:6][C:2]=1[NH:1][S:19]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)(=[O:21])=[O:20])[CH3:12]

Participants

3

Reactant 2

HCID 7369Benzenesulfonyl chlorideHCID 23372930166964-41-6

Product 1

HCID 18617378HCID 18617378, compoundYield 72%

Procedure

N-(4-Ethyl-3-trifluoromethyl-5-isoxazolyl)benzenesulfonamide was prepared, using the method of Example 90, from 5-amino-4-ethyl-3-trifluoromethylisoxazole and benzenesulfonyl chloride in 72% yield. Purification was achieved by recrystallization from ethyl acetate/hexanes to give white needles, m.p. 105°-106° C.

Workup

  1. customPurification
  2. customwas achieved by recrystallization from ethyl acetate/hexanes
  3. customto give white needles, m.p. 105°-106° C.

Sources & evidence

ORD record
ord-420e3c999a1b44b28b1d5e722ac49100
Source dataset
uspto-grants-1996_11
Patent number
US05571821

Reaction notes

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