1-Naphthalenesulfonyl chloride → HCID 23372947, compound

HRID 1899695Notes

Reaction equation

HRID 1899695 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([C:7]([F:10])([F:9])[F:8])[C:3]=1[CH2:11][CH3:12].[C:13]1([S:23](Cl)(=[O:25])=[O:24])[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][CH:14]=1>>[CH2:11]([C:3]1[C:4]([C:7]([F:10])([F:9])[F:8])=[N:5][O:6][C:2]=1[NH:1][S:23]([C:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][CH:14]=1)(=[O:25])=[O:24])[CH3:12]

Participants

3

Reactant 2

HCID 665601-Naphthalenesulfonyl chlorideHCID 23372930166964-41-6

Product 1

HCID 23372947HCID 23372947, compoundYield 70%

Procedure

N-(4-Ethyl-3-trifluoromethyl-5-isoxazolyl)-1-naphthalenesulfonamide was prepared, as described in Example 90, from 5-amino-4-ethyl-3-trifluoromethylisoxazole and 1-naphthalenesulfonyl chloride in 70% yield. Purification was achieved by recrystallization from methanol/water to give an off white solid, m.p. 135°-137° C.

Workup

  1. customPurification
  2. customwas achieved by recrystallization from methanol/water
  3. customto give an off white solid, m.p. 135°-137° C.

Sources & evidence

ORD record
ord-2cfbed6191f94d6ca8fd67aa99315bb1
Source dataset
uspto-grants-1996_11
Patent number
US05571821

Reaction notes

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