Benzenesulfonyl chloride → HCID 18617365, compound

HRID 1899697Notes

Reaction equation

HRID 1899697 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([C:7]([F:10])([F:9])[F:8])[C:3]=1[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[C:17]1([S:23](Cl)(=[O:25])=[O:24])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH2:11]([C:3]1[C:4]([C:7]([F:10])([F:9])[F:8])=[N:5][O:6][C:2]=1[NH:1][S:23]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)(=[O:25])=[O:24])[CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

Participants

3

Reactant 2

HCID 7369Benzenesulfonyl chlorideHCID 23372896HCID 23372896, compound

Product 1

HCID 18617365HCID 18617365, compoundYield 80%

Procedure

N-(4-Hexyl-3-trifluoromethyl-5-isoxazolyl)benzenesulfonamide was prepared as described in Example 42 from 5-amino-4-hexyl-3-trifluoromethylisoxazole and benzenesulfonyl chloride in 80% yield. Purification was achieved by recrystallizing the crude product from methanol/water to give a white needles, m.p. 128.5°-129° C.

Workup

  1. customPurification
  2. customby recrystallizing the crude product from methanol/water
  3. customto give a white needles, m.p. 128.5°-129° C.

Sources & evidence

ORD record
ord-71725dddca264c829c61ccd366f7d3e9
Source dataset
uspto-grants-1996_11
Patent number
US05571821

Reaction notes

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