Benzenesulfonyl chloride → HCID 23372898, compound

HRID 1899699Notes

Reaction equation

HRID 1899699 reaction equation
[C:1]1([S:7](Cl)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:11][C:12]1[O:16][N:15]=[C:14]([C:17]([F:20])([F:19])[F:18])[C:13]=1[CH3:21]>>[CH3:21][C:13]1[C:14]([C:17]([F:20])([F:18])[F:19])=[N:15][O:16][C:12]=1[NH:11][S:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)(=[O:9])=[O:8]

Participants

3

Reactant 2

HCID 7369Benzenesulfonyl chlorideHCID 156138784-Methyl-3-(trifluoromethyl)isoxazol-5-amine

Product 1

HCID 23372898HCID 23372898, compoundYield 72%

Procedure

This compound was prepared according to the method in Example 96 from benzenesulfonyl chloride and 5-amino-4-methyl-3-trifluoromethylisoxazole (see, U.S. Pat. No. 4,910,326 or corresponding EP A 0220947) in 72% yield as an off white solid after recrystallization from ethyl acetate/hexanes, m.p. 99.5°-100° C.

Workup

  1. customThis compound was prepared
  2. custom4,910,326 or corresponding EP A 0220947) in 72% yield as an off white solid after recrystallization from ethyl acetate/hexanes, m.p. 99.5°-100° C.

Sources & evidence

ORD record
ord-f45eaa8bdec94e4a9f4facde7171e414
Source dataset
uspto-grants-1996_11
Patent number
US05571821

Reaction notes

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