Benzenesulfonyl chloride → HCID 23372912, compound

HRID 1899701Notes

Reaction equation

HRID 1899701 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH2:7][CH3:8])[C:3]=1[CH3:9].[C:10]1([S:16](Cl)(=[O:18])=[O:17])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[CH2:7]([C:4]1[C:3]([CH3:9])=[C:2]([NH:1][S:16]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)(=[O:18])=[O:17])[O:6][N:5]=1)[CH3:8]

Participants

3

Reactant 2

HCID 7369Benzenesulfonyl chlorideHCID 47370323-Ethyl-4-methylisoxazol-5-amine

Product 1

HCID 23372912HCID 23372912, compoundYield 68%

Procedure

N-(3-Ethyl-4-methyl-5-isoxazolyl)benzenesulfonamide was prepared as described in Example 42 from 5-amino-3-ethyl-4-methylisoxazole and benzenesulfonyl chloride in 68% yield. Purification was achieved by preparative HPLC to give a white solid, m.p. 94°-95° C.

Workup

  1. customPurification
  2. customto give a white solid, m.p. 94°-95° C.

Sources & evidence

ORD record
ord-3bdff3fbbb5b4b99a76e822e3d0db85d
Source dataset
uspto-grants-1996_11
Patent number
US05571821

Reaction notes

Loading…