4-Bromo-3-methylisoxazol-5-amine → HCID 23445302, compound

HRID 1899718Notes

Reaction equation

HRID 1899718 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[CH2:9]([C:16]1[S:20][C:19]([S:21](Cl)(=[O:23])=[O:22])=[CH:18][CH:17]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[CH2:9]([C:16]1[S:20][C:19]([S:21]([NH:1][C:2]2[O:6][N:5]=[C:4]([CH3:7])[C:3]=2[Br:8])(=[O:23])=[O:22])=[CH:18][CH:17]=1)[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 104875194-Bromo-3-methylisoxazol-5-amineHCID 134257165-Benzylthiophene-2-sulfonyl chloride

Product 1

HCID 23445302HCID 23445302, compoundYield 22%

Procedure

5-Benzyl-N-(4-Bromo-3-methyl-5-isoxazolyl)thiophene-2-sulfonamide was prepared in the same manner as described in Example 2 from 5-amino-4-bromo-3-methylisoxazole and 5-benzyl-2-thiophenesulfonyl chloride in 22% yield. The product was purified by HPLC (5% CH3CN to 100% CH3CN over 30 min.) to give a solid, m.p. 49°-50° C.

Workup

  1. customThe product was purified by HPLC (5% CH3CN to 100% CH3CN over 30 min.)
  2. customto give a solid, m.p. 49°-50° C.

Sources & evidence

ORD record
ord-0a106859650b46edb9832421dae83f06
Source dataset
uspto-grants-1996_11
Patent number
US05571821

Reaction notes

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