4-Bromo-3-methylisoxazol-5-amine → HCID 22998417, compound

HRID 1899722Notes

Reaction equation

HRID 1899722 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[CH2:9]([C:17]1[CH:21]=[CH:20][S:19][C:18]=1[S:22](Cl)(=[O:24])=[O:23])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[CH2:9]([C:17]1[CH:21]=[CH:20][S:19][C:18]=1[S:22]([NH:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8])(=[O:23])=[O:24])[CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 104875194-Bromo-3-methylisoxazol-5-amineHCID 22998403HCID 22998403, compound

Product 1

HCID 22998417HCID 22998417, compoundYield 48%

Procedure

3-Phenethyl-N-(4-bromo-3-methyl-5-isoxazolyl)thiophene-2-sulfonamide was prepared in the same manner as described in Example 2 from 5-amino-4-bromo-3-methylisoxazole and 3-phenethyl-2-thiophenesulfonyl chloride in 48% yield. This was purified by HPLC (5% CH3CN to 100% CH3CN over 30 min.) to give a solid.

Workup

  1. customThis was purified by HPLC (5% CH3CN to 100% CH3CN over 30 min.)
  2. customto give a solid

Sources & evidence

ORD record
ord-0cecec3e83ba44e29bfc8f33e037da79
Source dataset
uspto-grants-1996_11
Patent number
US05571821

Reaction notes

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