Ammonia → HCID 23371382, compound

HRID 1899772Notes

Reaction equation

HRID 1899772 reaction equation
[ClH:1].C(O[N:5]=[CH:6][C:7]1[CH:22]=[CH:21][C:10]([O:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:9][CH:8]=1)C.[Cl-].[NH4+:24].N>C(O)C>[ClH:1].[C:6]([C:7]1[CH:22]=[CH:21][C:10]([O:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:9][CH:8]=1)(=[NH:5])[NH2:24]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 25517Ammonium ChlorideHCID 86749967HCID 86749967, compound

Product 1

HCID 23371382HCID 23371382, compoundYield 106.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A mixture of ethyl 5-[4-{1-(ethoxy)iminomethyl}phenoxy]valerate hydrochloride (28.2 g), ammonium chloride (4.8 g), ethanol solution of ammonia (42 ml) in ethanol (300 ml) was stirred and refluxed for 15 hours. After cooled to room temperature, the mixture was filtrated, and the filtrate was evaporated in vacuo, and the resulting precipitate was washed with diethyl ether to give ethyl 5-(4-amidinophenoxy)valerate hydrochloride (27.28 g).

Workup

  1. temperaturerefluxed for 15 hours
  2. filtrationthe mixture was filtrated
  3. customthe filtrate was evaporated in vacuo
  4. washthe resulting precipitate was washed with diethyl ether

Sources & evidence

ORD record
ord-70f819896a974b3caebd6195fcc7f254
Source dataset
uspto-grants-1996_11
Patent number
US05574016

Reaction notes

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