Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 140376928 | HCID 140376928 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 140376916 | HCID 140376916 | 91.9% |
Reaction Steps
A mixture of ethyl 5-[4-(N-benzyloxycarbonylamidino)phenoxy]valerate (17.4 g) in 10% hydrochloric acid (150 ml) and acetic acid (100 ml) was stirred at 50° C. for 1.5 hours. After cooled to room temperature, the reaction mixture was adjusted to pH≈4.0 with 4N sodium hydroxide solution. The resulting precipitate was collected by filtration to give 5-[4-(N-benzyloxycarbonylamidino)phenoxy]valeric acid (14.87 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05574016 |
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| Source dataset | uspto-grants-1996_11 |
|---|
| ORD ID | ord-6538ccc723cb40f58d473c64ce67fef2 |
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| Source note | uspto-grants-1996_11 |
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