HCID 74044237, compound → HCID 23371398, compound

HRID 1899777Notes

Reaction equation

HRID 1899777 reaction equation
[ClH:1].[C:2]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]=[CH:12][CH:13]=[CH:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:7][CH:6]=1)(=[NH:4])[NH2:3]>C(O)C.[Pd]>[ClH:1].[C:2]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:7][CH:6]=1)(=[NH:3])[NH2:4]

Participants

4

Reactant 1

HCID 74044237HCID 74044237, compound

Product 1

HCID 23371398HCID 23371398, compoundYield 95.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of ethyl 5-(4-amidinophenyl)-2,4-pentadienoate hydrochloride (20.00 g) and 10% Pd-C (5.00 g) in ethanol (500 ml) was stirred under H2 gas at room temperature for 3 hours. After filtration, the filtrate was evaporated in vacuo. The resulting precipitate was washed with diethyl ether to give ethyl 5-(4-amidinophenyl)pentanoate hydrochloride (19.42 g).

Workup

  1. filtrationAfter filtration
  2. customthe filtrate was evaporated in vacuo
  3. washThe resulting precipitate was washed with diethyl ether

Sources & evidence

ORD record
ord-f0f9ad1576c74999b11546757a82f233
Source dataset
uspto-grants-1996_11
Patent number
US05574016

Reaction notes

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