Ammonia → HCID 74044237, compound

HRID 1899780Notes

Reaction equation

HRID 1899780 reaction equation
[ClH:1].C(O[N:5]=[CH:6][C:7]1[CH:12]=[CH:11][C:10]([CH:13]=[CH:14][CH:15]=[CH:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:9][CH:8]=1)C.[NH3:22]>C(O)C>[ClH:1].[C:6]([C:7]1[CH:12]=[CH:11][C:10]([CH:13]=[CH:14][CH:15]=[CH:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:9][CH:8]=1)(=[NH:5])[NH2:22]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 74044238HCID 74044238, compound

Product 1

HCID 74044237HCID 74044237, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a mixture of ethyl 5-[4-{(1-ethoxy)iminomethyl}phenyl]-2,4-pentadienoate hydrochloride (22.00 g) in ethanol (220 ml) was poured 9N-ethanol solution of ammonia (19.7 ml) and refluxed for 15 hours. After cooled to room temperature, the reaction mixture was evaporated in vacuo, and the resulting precipitate was washed with diisopropyl ether to give ethyl 5-(4-amidinophenyl)-2,4-pentadienoate hydrochloride (20.15 g).

Workup

  1. temperaturerefluxed for 15 hours
  2. customthe reaction mixture was evaporated in vacuo
  3. washthe resulting precipitate was washed with diisopropyl ether

Sources & evidence

ORD record
ord-a15f800a88714600a0bf6e23d55b21d0
Source dataset
uspto-grants-1996_11
Patent number
US05574016

Reaction notes

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