HCID 67734590, compound → HCID 131719467, compound

HRID 1899785Notes

Reaction equation

HRID 1899785 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][CH:10]=[C:11]([CH:13]=[CH:14][C:15]3[CH:28]=[CH:27][CH:26]=[CH:25][C:16]=3/[C:17](/[O:23][CH3:24])=[CH:18]\[C:19]([O:21][CH3:22])=[O:20])[N:12]=2)=[CH:4][CH:3]=1.[H][H]>CO.[Pd]>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][CH:10]=[C:11]([CH2:13][CH2:14][C:15]3[CH:28]=[CH:27][CH:26]=[CH:25][C:16]=3/[C:17](/[O:23][CH3:24])=[CH:18]\[C:19]([O:21][CH3:22])=[O:20])[N:12]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 67734590HCID 67734590, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 131719467HCID 131719467, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

3 g (7.6 mmol) of methyl 2-{2-[2-(4-fluorophenyl)-4thiazolyl]-(Z)-ethenyl}-(E)-β-methoxycinnamate in 100 ml of methanol are hydrogenated in the presence of 0.2 g of Pd/C (10%) under a gage pressure of 0.05 bar of hydrogen and at 20°-25° C. until hydrogen uptake ceases (1 h). The mixture is then filtered and concentrated.

Workup

  1. filtrationThe mixture is then filtered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-483f414ae48b4c3fba8ce1af7944492e
Source dataset
uspto-grants-1996_11
Patent number
US05573999

Reaction notes

Loading…