Acetic Acid → HCID 86749969, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 0.5 g (approximately 1 mmol) crude 1-(t-butylcarbonyloxy)-3,5-bis(acetyl)-2-deoxy-2,2-difluororibose in tetrahydrofuran (5 ml) cooled to -65° C. were added 2.0 ml of a 1M solution of potassium t-butoxide in tetrahydrofuran (2 mmol) dropwise and the reaction mixture stirred 1 hour at -65° C. The reaction was then quenched with 0.23 ml of glacial acetic acid (4 mmol) and allowed to warm to room temperature. The reaction mixture was concentrated under reduced pressure to give 0.43 gm 1-(t-butylcarbonyloxy)-5-acetyl-2-deoxy-2,2-difluororibose. Mass spec. m/e=390=P+1.

Provenance & Evidence