Methanol → HCID 23371625, compound

HRID 1899808Notes

Reaction equation

HRID 1899808 reaction equation
[OH:1][CH:2]([C:17]1[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=1)[CH2:3][N:4]1[CH2:9][CH2:8][C:7]([C:10]2[S:11][CH2:12][C:13](=[O:16])[NH:14][N:15]=2)=[CH:6][CH2:5]1.S(=O)(=O)(O)O.[OH-].[Na+].[CH3:32]O>>[CH3:32][O:1][CH:2]([C:17]1[CH:18]=[CH:19][C:20]([O:23][CH3:24])=[CH:21][CH:22]=1)[CH2:3][N:4]1[CH2:9][CH2:8][C:7]([C:10]2[S:11][CH2:12][C:13](=[O:16])[NH:14][N:15]=2)=[CH:6][CH2:5]1

Participants

5

Reactant 4

HCID 887MethanolHCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 15290063HCID 15290063, compound

Product 1

HCID 23371625HCID 23371625, compound

Procedure

2-[1-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]-1,2,5,6-tetrahydropyrid-4-y1]-4H,6H-1,3,4-thiadiazin-5-one (150 mg, 0.43 mmol) was dissolved in methanol (5 ml), added with concentrated sulfuric acid (0.8 ml, 15 mmol) and refluxed with heating for four hours. The solution was poured into ice water and neutralized with 2N aqueous sodium hydroxide.

Workup

  1. temperaturerefluxed
  2. temperaturewith heating for four hours

Sources & evidence

ORD record
ord-127a9675795f4a36b4156f1f403c5373
Source dataset
uspto-grants-1996_11
Patent number
US05574033

Reaction notes

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