Fumaric Acid → HCID 10006016, compound

Participants

Reaction Steps

5-Benzyl-3-(3-morpholino-1-phenylpropyl)-1,3-oxazolidin-2-one (diastereomer A) (376 mg, 1.0 mmol) prepared in Example 1 was dissolved in ethanol (5 ml). To the solution, fumaric acid (115 mg, 1.0 mmol) was added and dissolved under heating. From the resulting solution, ethanol was removed by distillation under reduced pressure, and then the residue was crystallized from ethanol/hexane (3/1). The obtained crystalline product was collected by filtration, washed with ethanol/hexane (3/1), and dried under reduced pressure overnight at room temperature to give 234 mg of the titled compound as a white crystalline powder (yield: 46%).

Provenance & Evidence