Fumaric Acid → HCID 67623585, compound

Participants

Reaction Steps

5-(2-Bromophenyl)methyl-3-[3-(4-hydroxypiperidino)-1-phenylpropyl]-1,3-oxazolidin-2-one (237 mg, 0.5 mmol) prepared in the same manner as is described in Example 5 and fumaric acid (53 mg, 0.5 mmol) were dissolved in ethanol (3 ml) under heating. From the resulting solution, ethanol was removed by distillation under reduced pressure. Water was added to the residue and then the resulting solution was concentrated. After the concentration was repeated for three times, the residue was dried in vacuum. The dried residue was crushed to obtain 280 mg of the titled compound as a white powder.

Provenance & Evidence