HCID 9993062, compound → 5-Fluoro-1,2,3,4-tetrahydroquinoxalin-2-one

HRID 1899931Notes

Reaction equation

HRID 1899931 reaction equation
C(OC([N:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][C:16]=2[F:18])[NH:11][C:10](=[O:19])[CH2:9]1)=O)(C)(C)C>CO>[F:18][C:16]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:17]=1[NH:8][CH2:9][C:10](=[O:19])[NH:11]2

Participants

3

Reactant 1

HCID 9993062HCID 9993062, compound

Product 1

HCID 229128785-Fluoro-1,2,3,4-tetrahydroquinoxalin-2-one

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 4-(ten-butyloxy)carbonyl-5-fluoro- 1,2,3,4-tetrahydroquinoxalin-2-one (XXII, EXAMPLE 23, 6.13 g) in 75 ml of methanol saturated with HCI(g) is stirred at 20°-25° for 7.5 hr. The solvent is then removed under reduced pressure and aqueous sodium bicarbonate is added to the residue. The solid is collected and washed with a small amount of water and then dichloromethane and dried to give the title compound, mp 246°-248° NMR (CDCl3) 4.04, 4.10, 6.54, 6.63-6.74 and 8.54 δ.

Workup

  1. customThe solvent is then removed under reduced pressure and aqueous sodium bicarbonate
  2. additionis added to the residue
  3. customThe solid is collected
  4. washwashed with a small amount of water
  5. dry with materialdichloromethane and dried

Sources & evidence

ORD record
ord-a5378b778a274648b04cdcfa100bfdbe
Source dataset
uspto-grants-1996_11
Patent number
US05574038

Reaction notes

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