tert-Butyl isocyanoacetate → tert-Butyl (S)-12,12a-dihydroimidazo[1,5-a]pyrrolo[2, 1-c]quinoxaline-1-carboxylate

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Reaction Steps

Following the general procedure of EXAMPLE 30 and making non-critical variations but starting with (S)-3,3a-dihydropyrrolo[1,2-a]quinoxaline-1,4(2H,5H)-dione (intermediate formed in EXAMPLE 282, 0.638 g) and tert-butyl isocyanoacetate (0.621 g), the title compound is obtained, mp 202°-207° (decomp); MS (m/z) at 325; IR (mineral oil) 1719, 1363, 1700, 1507, 1161, 1293 cm-1 ; NMR (CDCl3) 1.64, 2.25-2.40, 2.55-2.81, 3.31-3.41, 5.26, 7.23-7.29, 7.33, 7.52, 8.06, 8.34 δ; [α]D =-248° (0.96, methanol).

Provenance & Evidence